EFFECT ON THE OSTEOBLASTS: POMACTIV® HFV
Effects :
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Mechanisms of action :Two types of cells, the osteoblasts (which build the bones) and the osteoclasts (which destroy the bones) intervene in the process of bone formation and destruction. In vitro tests have shown that the addition of Pomactiv® Hfv into the culture medium directed the differentiation of strain cells towards osteogenesis. This mechanism of action is detailed in the animation above. |
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STIMULATION OF the OSSEOUS MINERALIzATION and OSTEOBLASTS synthesis
An in vitro study was undertaken by Val de Vire Bioactives. Its purpose was to evaluate the effects of Pomactiv® Hfv on the differentiation of strain cells into osteoblasts. The results showed an activity on 2 identified markers :
1 : A great increase of the alkaline phosphatase (PAL) gene expression and activity into the cells. This enzyme is involved in the osseous mineralization and responsible for calcium fixation on the bones.
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2 : A repression of Transforming Gross Factor beta 1 (TGFβ1), growth factor which may act in the differentiation of the strain cells into osteoclasts (cells destroying the bone).
Antioxidant ACTION
Polyphenols play a part in the prevention of osseous resorption. When the organism is affected by oxidative stress, (drop of the endogenous redox system of defence due to an excess of superoxide anions (free radicals) and a deficit in antioxidant molecules), there is an imbalance in the osseous cells production. This imbalance stimulates the osteoclasts synthesis and activity, increasing the osseous resorption. That is why it is essential to have a sufficient antioxidants intake to preserve bony resources. Pomactiv® Hfv is 4 times more antioxidant than pure Vitamin C (regarded up to now as one of the base antioxidants) or 5 times more antioxidant than pure Vitamin E.
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