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ANTI-AGEing EFFECT : POMACTIV® HFV

Effects :

Antioxidant protection
Stimulation of the tissue repair and renewal

Mechanisms of action :

Skin wellbeing is related to the abundance of collagen and elastin (which characterizes its elasticity) and also relies on the balance between proteins synthesis and degradation. Many molecules are responsible for the regulation of this system: growth factors, cytokines, receptors, enzymes (proteases), proteins of structure (collagen, elastin). Pomactiv® Hfv acts on the expression of many genes taking part in the dermal renewal process.

The efficiency of Pomactiv® Hfv was demonstrated by in vitro test made on aged human dermal fibroblasts (cf. Antioxidant effect). The screening of the genes showed the action of Pomactiv® Hfv on anti-ageing markers, and its capacity to relaunch the renewal process of aged fibroblasts. The study gave the results hereafter:

Modification of the expression of the growth factors, cytokines, and receptors.
Significant modification of the expression of some collagen genes.
Overexpression of the decorin gene; decorin is a protein often used as anti-wrinkle marker: The rate of decorin is regarded as good marker of the potential formation or disappearance of wrinkles. This protein is essential for the control and correct collagen formation.
Repression of an inflammatory gene marker: the excessive production of prostaglandin (PGE) is an inflammatory marker. The PGE acts by means of a receptor, here repressed by Pomactiv® Hfv. Thus, the inflammation is controlled or repressed.
Overexpression of the telomerase gene: the senescence of cells means a deceleration, then a irreversible stop of their multiplication. The senescence markers are morphological deterioration, shortening of the telomers, and loss of the proliferative process. The enzyme telomerase is the only one able to maintain the size of the telomers, and thus to restore the proliferative potential of the cells.
Regulation of the proteases genes: Proteases are essential in the restructuring of proteins responsible for the support of the skin.

Pomactiv® Hfv (named Pomactiv® Cqr for cosmetic applications) efficiency in cosmetic formulations was also proved by clinical tests (more).

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