INHIBITION OF SUGARS ABSORPTION : POMACTIV® HFV
Effects :
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Mechanisms of action :Phloridzin and quercetin are competitive inhibitors of sugar transmembrane absorption. Adding these apple actives to daily diet allow to reduce or to delay the sugar absorption. |
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Phloridzin is a trap molecule which misleads the intestinal receptor responsible for the introduction of glucose into cells. Phloridzin affinity with this receptor is 1000 times superior to the glucose one.
Glucose is the sole molecule able to cross the cellular membrane. Phloridzin has the capacity to fix on the glucose receptor to make it momentary not available for the assimilation of surrounding glucose.
Quercetin has the same effect as phloridzin on glucose receptor, but is also able to fix on other sugar receptors (galactose, rhamnose...)
One of the main roles of adipocytes (fat cells) is to store the excess of sugar into fat. By limiting the quantity of sugars assimilated by the cells, their accumulation and transformation into lipids is limited.
Pomactiv® Hfv slimness properties have been proved by in vitro studies. Morphological observations made on cells cultures, grown on a medium promoting the differentiation of the pre-adipocytes into adipocytes, gave the following results.
Morphological studies of cells cultures through coloration of intracellular lipidic masses have shown that Pomactiv® Hfv extract significantly inhibit lipids accumulation into differentiated cells. |
These results have been confirmed by further studies regarding the expression of genes involved in pre-adipocyte/adipocyte differentiation. Pomactiv® Hfv repress the expression of PPARζ gene (Peroxisome Proliferator Activited Receptor Gamma). The increase of PPARζ rate is related to an increasing differentiation of pre-adipocytes into adipocytes. Through repressing effect, Pomactiv® Hfv limits the capacity of pre-adipocytes to differentiate into adipocytes.
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